Probing Two-pore channel 2 in LRRK2-Parkinson’s in vivo
Parkinson’s disease is a major cause of disability in the elderly, the second most common neurodegenerative disorder above 60 years of age. Mutations in a large gene, LRRK2, have been linked to Parkinson’s. In a number of model organisms, expression of LRRK2 mutations recapitulates the loss of dopaminergic neurons and consequent movement deficits. This project focuses on the effects of LRRK2 in the genetically amenable organism, Drosophila. In particular, it focuses on the role of LRRK2 at the lysosome, the recycling organelle. We have a number of new genetic manipulations of the two-pore channel and novel compounds that may provide a disease-modifying therapy. The appointee will work in a lab, with other technicians, 2 research students and a post-doc all working on a range of neurodegenerative problems. This project is funded by a grant to Prof Sandip Patel (UCL), Dr Chris Elliott and Dr Sean Sweeney (York) from Parkinson’s UK.
Interview date: 13th October 2021
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