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Based at
University of York - Heslington Campus
Hours of work
Contract status
Fixed term
26,341 - 32,344 per year
Interview Date
13th October 2021
Posted Date
Apply by
Job Reference

Role Description

Biology Department

Probing Two-pore channel 2 in LRRK2-Parkinson’s in vivo

Parkinson’s disease is a major cause of disability in the elderly, the second most common neurodegenerative disorder above 60 years of age. Mutations in a large gene, LRRK2, have been linked to Parkinson’s. In a number of model organisms, expression of LRRK2 mutations recapitulates the loss of dopaminergic neurons and consequent movement deficits. This project focuses on the effects of LRRK2 in the genetically amenable organism, Drosophila. In particular, it focuses on the role of LRRK2 at the lysosome, the recycling organelle. We have a number of new genetic manipulations of the two-pore channel  and novel compounds that may provide a disease-modifying therapy. The appointee will work in a lab, with other technicians, 2 research students and a post-doc all working on a range of neurodegenerative problems.  This project is funded by a grant to Prof Sandip Patel (UCL), Dr Chris Elliott and Dr Sean Sweeney (York) from Parkinson’s UK.


  • To provide technical and scientific support to research project in the laboratory. This will involve maintenance of Drosophila stocks, and characterisation of the novel mutations.
  • Maintain accurate records of work undertaken, including reports, using appropriate (bespoke) software.
  • Liaise with appropriate staff and external service providers to ensure the work area and equipment are kept operational

Skills, Experience & Qualification needed

  • HNC, HND, Degree or equivalent in appropriate science discipline or appropriate experience
  • Relevant theoretical knowledge in Biology
  • In depth knowledge of relevant safety regulations and procedures for example, COSHH and risk assessment
  • Knowledge and ability to implement practical techniques used in relevant work area
  • Evidence of having contributed to activities using a variety of sometimes specialist technical skills
  • Experience of Molecular Biology (e.g. PCR, Western Blotting); training in fly work is not assumed and can be provided but will be advantageous
  • Experience of working  on own initiative and as part of a team

Interview date: 13th October 2021

For informal enquiries: please contact Chris Elliott on or Louise Simpson on

Athena Gold 2017 




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