A 2-year, fixed-term postdoctoral research associate position is available to work with Dr Andrew Mason and Professor Jennifer Southgate in the Jack Birch Unit for Molecular Carcinogenesis, part of the Department of Biology and York Biomedical Research Institute at The University of York. We are seeking a bioinformatics-focused researcher with a strong biological background to complete a single-cell transcriptomics project with time split between the laboratory (c.25%) and the terminal (c.75%).
The successful candidate will join an international consortium recently funded by the Wellcome Leap Human Organs, Physiology and Engineering (HOPE) programme. Our exciting body of work seeks to utilise the Jack Birch Unit’s expertise in ureteric biology to increase progress in the development of therapeutically-tractable kidney organoids derived from human pluripotent stem cells. Your role will be to process primary tissue samples from histologically normal adult ureter, to perform a broader single-cell characterisation of the tissue beyond our current and ongoing study of urothelium. You will utilise both standard single cell suspensions and develop the unit’s capability to perform spatial transcriptomics, including setting up the 10x Visium in the laboratory and developing the bioinformatic workflow. Following this augmented characterisation, you will compare these data to those derived from reprogrammed human cells, and from the engineered organoids.
The postdoctoral research associate will lead the transcriptomic characterisation of human ureteric tissue, informing how the incorporation of a ureter to a kidney organoid affects function and form. You will process primary human samples for single-cell RNAseq, advancing and refining existing bioinformatic approaches and expertise. You will set up the 10x Visium platform for spatial transcriptomics in the laboratory, and derive an up to date workflow for the bioinformatic analyses of these data. More broadly, you will provide bioinformatic support to the analysis of omics datasets across the consortium.
Interview date: Friday 29th October 2021
For informal enquiries: Please contact Dr Andrew Mason (firstname.lastname@example.org) directly with any questions or to arrange an informal discussion, or, alternatively, email@example.com with any other questions.
York is one of the most successful universities in the UK.
With world-class activity across the spectrum from the physical sciences, life sciences, and social sciences to the humanities, we have been recognised as one of the top 100 universities in the world, gaining outstanding results in official assessments of our research and teaching.