A research associate post is available for up to 48 months in the York Structural Biology Laboratory, part of the Department of Chemistry; working in the group ofDr Jamie Blaza, a UKRI Future Leader Fellow, on the project ‘Energy metabolism and antibiotic action in the tuberculosis pathogen’. The role is interdisciplinary, integrating biophysics, microbiology and biochemistry. We encourage applicants from any relevant background as long as you have a passion for learning new techniques and subject matter.
You will investigate the structure and mechanisms of important respiratory chain complexes both in, and isolated from, living mycobacteria. You will use functional biophysical assays, electron cryo-microscopy (cryoEM), and microbiology to understand the mechanism of these complexes, how they integrate into the biology of the organism, and how these processes might be attacked to develop new antibiotics.
TheDepartment of Chemistry is one of the largest and most successful departments at York and we are renowned internationally for our research. As a department, we strive to provide a working environment that allows all staff and students to contribute fully, to flourish, and to excel. We are proud of our Athena SWAN Gold Award.
To conduct research under the supervision of senior colleagues, specifically to:
○ Grow mycobacteria in different defined growth conditions to induce specific respiratory chains.
○ Isolate the membrane-bound respiratory enzymes of interest in intact, active states.
○ Carry out biochemical characterisation of enzymes
○ Subject isolated enzymes to high-resolution cryoEM
○ Combine different types of data to build a comprehensive understanding of how and why the enzymes function.
Where appropriate you will:
Interview date: tbc
For informal enquiries: please contact Jamie Blaza at email@example.com
The University is committed to promoting a diverse and inclusive community – a place where we can all be ourselves and succeed on merit. We offer a range of family friendly, inclusive employment policies, flexible working arrangements, staff engagement forums, campus facilities and services to support staff from different backgrounds.
A place where we can ALL be ourselves #EqualityatYork
York is one of the most successful universities in the UK.
With world-class activity across the spectrum from the physical sciences, life sciences, and social sciences to the humanities, we have been recognised as one of the top 100 universities in the world, gaining outstanding results in official assessments of our research and teaching.