The UK:Brazil Joint Centre Partnership in leishmaniasis (JCPiL; funded by the MRC/FAPESP) offers two Postdoctoral Positions to work on the project "Epigenetic regulation of Leishmania gene expression" in the laboratories of molecular parasitology under the supervision of Prof. Angela K. Cruz (University of São Paulo, Ribeirão Preto, Brazil) and Drs. Pegine Walrad and Michael Plevin (York Biomedical Research Institute, Dept of Biology, University of York, UK) as part of the UK:Brazil Joint Centre Partnership in leishmaniasis (JCPiL); involving 12 collaborative research groups from the UK and Brazil. The appointed postdoctoral fellows will study the putative regulatory role of novel non-coding RNAs (Brazil-based role) and identify and characterise RBPs which bind and regulate these ncRNAs (University of York based role).
You will conduct research about Leishmania spp. gene regulatory pathways and associated parasite vulnerabilities using an iterative, multidisciplinary approach (in silico, in vitro and in vivo models). Using appropriate research techniques and methods, you will analyse and interpret research data, write up research results and disseminate these through publications, presentations and outreach activities. You will molecularly validate and investigate novel ncRNAs isolated from a bespoke in silico pipeline; identifying associating factors and determining functional connections to lifecycle progression, infectivity and resultant pathologies. We are particularly interested in the isolation and functional characterisation of associated RNA binding proteins. There will be opportunities to develop software pipelines and other tools to successfully analyse data collected across these scales.
You should have a PhD (or be in the final stage of completing your PhD) in a relevant field such as molecular cell biology, parasitology, molecular genetics, microbial pathogenesis, or biochemistry. Particular skills in molecular biology, genetics and cell biology techniques are required with experience in RNA and/or parasite biology highly desirable. You should be highly motivated, have a willingness to learn, and be able and willing to work independently. Candidates should possess very good oral and written communication skills in English. You will be expected to be supportive to other members of the research group and Institute, and assist in the training of students. Active participation in lab meetings and seminar series attendance is required.
You will have experience in quantitative approaches applied to biochemistry and molecular biology. Preference will be given to candidates with cell culture experience, particularly kinetoplastid and Leishmania parasites. You should be highly motivated, and able to engage with colleagues and students to ensure efficient data management. A working knowledge of molecular parasitology and gene regulatory networks is highly desirable.
The University of York role is is a fixed term contract available for a period of up to 18 months full time within the salary range £32,817 to £40,322 a year. Targetted start date is 5 January 2020.
Interview date: 9 December 2019
For informal enquiries: please contact Dr. Pegine Walrad, (email: email@example.com, tel: +44 (0)1904 328918).
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