We are looking for a highly qualified full-time Postdoctoral Research Associate to join the group of Dr. David Kent based in the Department of Biology at the University of York.
The position will explore a new and exciting area of stem cell biology with potential implications for disease evolution and stem cell expansion: the physical biology of blood stem cells. This postholder will explore the impact of physical forces on the fate choices of highly purified single blood stem cells and develop tools to help expand blood cells outside the body. The Kent laboratory's research focuses on understanding cell fate decisions in normal and malignant blood stem cells. We have recently pioneered approaches in single cell biology which link single stem cell function to single cell gene expression (Wilson et al, Cell Stem Cell; Nestorowa et al., Blood; Shepherd et al., Blood 2018) and determined that the order of mutation acquisition impacts disease evolution and clinical features of blood cancers (Ortmann et al., NEJM).
The successful candidate must hold a PhD (or equivalent experience) in a relevant subject and have research laboratory experience with expertise in engineering and physical biology. Particular expertise in materials science, nanofabrication, and microfluidic device design/construction are desirable. Experience or exposure to the fields of stem cell biology, immunology, flow cytometry, and molecular biology will be an asset. The successful candidate will have a track record of research excellence and communication skills.
Once appointed, you will undertake research that falls under the umbrella of normal and malignant single stem cell biology with a particular focus on understanding the physical biology of blood stem cells. You will drive an independent project but also to work closely with other lab members. You will also be responsible for the writing up of research results and dissemination through publications, seminar and conference presentations and public engagement and outreach activities. Opportunities for mentorship and additional collaborations will be available and encouraged.
This position is funded by ERC.
The post is full-time, fixed term for 2 years and salary will be in the range £32,236 - £39,609 per annum.
Informal enquiries are welcomed and should be made to Dr. David Kent via email: email@example.com. For an alternative contact, please email firstname.lastname@example.org.
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