A full-time three-year post-doctoral research associate position is available to investigate the biosynthesis of alkaloids from Daphniphyllum plants. Understanding the unique biosynthesis of these complex compounds will lead to the generation of novel biocatalysts and bioactive compounds. The project is based in the laboratory of Dr Benjamin Lichman, a UKRI future leader fellow. The Lichman lab has expertise in plant natural products, gene discovery and enzymology.
You will conduct individual and collaborative research projects; present research results at national and international meetings; and write manuscripts for publication in high-impact journals. Specifically, you will discover and characterise new and unusual enzymes involved in the biosynthesis of plant alkaloids, with a primary focus on gene discovery, recombinant expression and enzyme characterisation. You will also have opportunities to explore approaches such as synthetic biology or X-ray crystallography.
You should have a PhD in biochemistry (or a related subject) and experience of recombinant protein expression and biochemical assays. Previous experience of successful work in natural product enzymology and/or biosynthetic pathway elucidation would be a significant advantage. Excellent communication skills are essential. You should have a commitment to personal development, a collaborative ethos and an enthusiasm for research in plant natural product biosynthesis.
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