A fixed term postdoctoral appointment is available, for up to 48 months, in the York Structural Biology Laboratory, part of the Department of Chemistry, to work in the group of Professor Fred Antson, on a Wellcome Turst-funded project entitled ‘Structure and mechanism of nucleic acid-processing machines in viral biogenesis’.
The Department of Chemistry is one of the largest and most successful academic departments at York. The Department was placed in the top ten UK universities for Research Power by the 2014 Research Excellence Framework exercise (REF). As a Department we strive to provide a working environment which allows all staff and students to contribute fully, to flourish, and to excel. We are proud of our Athena SWAN Gold Award.
The University of York is a member of the Russell Group of research-intensive UK universities. The recent Research Excellence Framework (REF) confirmed the position of the University among the leading institutions in the UK for research. The proportion of research activity of world-leading, 4* status is among the highest of any UK university, and York is rated tenth out of 155 higher education institutions for the impact of its research.
You will conduct research under the supervision of senior colleagues. You will focus on producing and purifying bacteriophage capsids that can package DNA in vitro, and performing structural studies of DNA packaging complexes by Cryo-EM. To assist in the identification and development of potential areas of research and the development of proposals for independent or collaborative research projects. You will need a good understanding of a range of research techniques and methodologies to include protein production and purification, isolation and production of viral capsids, in vitro nucleic acid packaging activity assays and reconstruction of 3D structure from images of single particles recorded by Cryo-EM.
The post is available immediately on a full-time basis.
Skills, Experience & Qualification needed
You are expected to have a first degree in Chemistry, Biology or a related discipline and a PhD in Structural Biology or equivalent experience. You will have experience in structural biology, with specific experience in purification and production of viral capsids, in vitro nucleic acid packaging activity assays, Cryo-EM 3D structure reconstruction. You will need to have a commitment to high quality, a collaborative approach and a willingness to work proactively with others.
You will also have:
The post is fixed-term for up to 48 months and available immediately.
Salary from £31,604 - £38,832 on grade 6 of the University’s salary scales
Informal enquiries can be made to Professor Fred Antson (firstname.lastname@example.org)
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