This is an exciting opportunity to join a vibrant department that welcomes staff and students from around the world. We celebrate excellence, breadth and diversity across the spectrum of modern biology.
Formation of antibiotic-resistant staphylococcal biofilms on medical devices causes significant morbidity and mortality. Staphylococcus aureus and Staphylococcus epidermidis are two commonly-isolated organisms from device infections. This British Heart Foundation-funded project is investigating both the structure and function of proteins involved in staphylococcal biofilm formation.
Key responsibilities of this role include: to conduct individual and collaborative research projects; to contribute to the preparation of research proposals and applications to external bodies; to undertake appropriate supervision, organisational and administrative activities connected to the research project; to develop and initiate collaborative working internally and externally; participation in and identification of external networks in order to share information and identify potential opportunities for collaboration and possible sources of funding; to provide guidance to other staff and students, as required, as well as coordinating the work of small research teams and to assist with undergraduate teaching in own area of expertise.
You should have a PhD in biochemistry or biophysics and previous experience of recombinant expression and purification of proteins, protein structure determination using X-ray crystallography and analysis of proteins and molecular interactions using a range of biophysical techniques. You should have experience of supervising undergraduate or graduate students in the lab, a track-record of research publications and keen interest in the structure and function of bacterial proteins involved in infection. A wide range of equipment is available for the work and the successful applicant will also gain experience of interdisciplinary collaborative working. You will need to be able to work independently as well as being able to lead a team.
Relevant publications from the lab:
Gruszka, D. T. et al. Staphylococcal biofilm-forming protein has a contiguous rod-like structure. Proc Natl Acad Sci U SA 109, E1011-1018 (2012).
Gruszka, D. T. et al. Cooperative folding of intrinsically disordered domains drives assembly of a strong elongated protein. Nat Commun 6, 7271 (2015).
In addition to the candidate brief provided, you may also wish to make informal contact with Professor Jennifer Potts firstname.lastname@example.org For an alternative contact, please email email@example.com
This post is available on a fixed term basis for up to 27 months.
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