A fixed term research fellow position is available until the end of July 2022 to study the structure and mechanism of protein-nucleic acid motor assemblies by cryo-electron microscopy, working with Professor Fred Antson and members of his research group. This post can be full time or part time (at least 50% FTE).
The Department of Chemistry is one of the largest and most successful academic departments at York. The Department was placed in the top ten UK universities for Research Power by the 2014 Research Excellence Framework exercise (REF). As a Department we strive to provide a working environment which allows all staff and students to contribute fully, to flourish, and to excel. We are proud of our Athena SWAN Gold Award.
The University of York is a member of the Russell Group of research-intensive UK universities. The recent Research Excellence Framework (REF) confirmed the position of the University among the leading institutions in the UK for research. The proportion of research activity of world-leading, 4* status is among the highest of any UK university, and York is rated tenth out of 155 higher education institutions for the impact of its research.
Using Cryo-EM, you will analyse the structure and mechanism of genome packaging motors of dsDNA viruses. In addition, you will analyse the role of each component of the DNA-translocating motor, and molecular interactions between individual protein components and DNA. You will adopt existing software or develop new software suitable for asymmetric reconstruction of motor proteins assembled on large virus particles. You will be expected to lead the development and application of micro-ED technique to projects within the research group and develop strategies for further studies.
You will participate in applications for major research awards, as a Researcher Co-I and supervise the work of others; providing expert advice and guidance as well as disseminating your research findings through publications and presentations at conferences.
Skills, Experience & Qualifications needed
You are expected to have a PhD level qualification in Structural biology, biochemistry or biophysics with substantial prior experience in structural studies and mechanistic analysis of nucleic acid motor proteins. Prior experience in the X-ray or Cryo-EM structure determination and software development is essential. The post also requires substantial prior experience in preparing and handling protein-nucleic acid complexes.
You will have the proven ability to plan, develop and advance research projects and proposals and identify sources of funding and contribute to the process of securing internal and external funds and the proven ability to take responsibility for identified parts of a large research project and supervise the work of others, providing expert advice and guidance.
You will have highly developed communication skills to engage effectively with a wide ranging audience, both orally and in writing, using a range of media and evidenced by the presentation of papers at conferences and the publishing of papers in academic journals.
The post is available immediately and has flexibility with regard to being part-time or full-time.
Informal enquiries can be made to Professor Fred Antson (firstname.lastname@example.org)
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