Using zebrafish models to understand the neuropathology of rare diseases
Leukodystrophies are rare diseases affecting specific areas of the brain called the white matter. This consists mainly of a protective insulating sheath (myelin) surrounding our nerve cells. Over 100 leukodystrophies have been described but due to the rarity of limited research available, there is little understanding of the mechanisms of the pathology and limited treatments are available. As part of the LEUKOLABS network founded by the supervisor and colleagues to bring together clinical and research leukodystrophy experts, we developed multiple zebrafish models for those rare diseases. We have made a model for Krabbe Disease, a particularly devastating leukodystrophy, which will be the main focus of this project. The post holder will analyse the contribution of the immune system to the development of the pathology, using already established imaging assays in the transparent zebrafish. This project is part of a multi-disciplinary team with colleagues working in parallel on iPSC-models in the US.
This is a unique opportunity to develop your research skills in an exciting and clinically relevant environment. Applicants must have experience in laboratory work, and due to the short-term contract, preference will be given to candidates with experience in zebrafish in vivo work and/or molecular biology techniques.
This project is funded by a research grant to Dr Noémie Hamilton (York) from The Legacy of Angels Foundation.
Interview date: 6 July 2023
For informal enquiries: Please contact Dr Noémie Hamilton by email at firstname.lastname@example.org
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