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This project is collaborative between researchers in the Physics of Life and Photonics research groups in the School of Physics, Engineering and Technologyy. The successful candidate will work under the supervision of Dr Steven Quinn and in close collaboration with Prof Thomas Krauss, both in the School of Physics, Engineering and Technology. The post is expected to start on October 2nd, 2023.
The aim of the research is to develop, test and apply a novel optical biosensing technology based on guided mode resonances (GMRs) to detect and monitor protein levels implicated in Alzheimer’s disease. Specifically, the role holder will develop and apply robust chemistries on the photonic biosensor surface, investigate approaches to detect multiple proteins in parallel, assess the sensor’s limit of detection and use the sensor to quantify protein levels in patient blood samples.
The sensor that will be developed further during the project is based on the principle of GMRs that have previously detected protein concentrations as low as 1 pg/mL. This project will leverage recent advances in GMR sensor chip design and nanofabrication, microfluidics and surface-immobilization techniques to develop a portable, and sensitive detector of blood-based biomarkers of Alzheimer’s disease. Additionally, the research associate will use advanced biophysical instrumentation, including single-molecule fluorescence and electron microscopy tools, and biochemical approaches including enzyme-linked immunosorbent assays to confirm protein morphology and abundance. The photonic biosensor will be developed in close collaboration with Phorest Diagnostics, a digital healthcare company developing blood tests for home and community use, providing an exciting opportunity for the successful candidate to engage with commercialization processes. The role holder will also contribute to developing and optimizing instrumentation, with the long-term goal of developing a commercial product to support early-stage Alzheimer’s diagnosis. Experience of working collaboratively, on a highly interdisciplinary research project is essential for this role.
Please note that this role involves working with human blood samples.
Skills, Experience & Qualification needed
You will have:
• First degree in Physics, Engineering, Biochemistry or related discipline.
• PhD in Physics, Engineering, Biochemistry or equivalent experience
• Knowledge of optical instrumentation
• Highly developed communication skills to engage effectively with a wide ranging audience, both orally and in writing, using a range of media
• Experience of carrying out both independent and collaborative research in optical sensing
Interview date: TBC
For informal enquiries: please contact Dr Steven Quinn (firstname.lastname@example.org), Prof Thomas Krauss (email@example.com) or Simone Quinn (firstname.lastname@example.org), if you would like to learn more about working in the School of Physics, Engineering and Technology at York.
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