Research Associate
Role Description
Department
The Cell Surface Signalling laboratory led by Professor Gavin Wright is interested in identifying the molecular basis of cellular recognition processes in both health and disease. The aims of the laboratory’s research is to understand how cells interact both within our own bodies and with pathogens to inform the rational design of novel intervention strategies for the treatment and prevention of genetic and infectious diseases. We have a current focus on investigating host-pathogen interactions and developing vaccines for parasitic diseases. The Hull York Medical School and associated Department of Biology and York Biomedical Research Institute are recognised world leaders in biochemistry and parasitology research and you will join a vibrant environment of scientific researchers who are dedicated to tackling these important problems in global health.
Role
You will be a postdoctoral-level researcher with interests in the molecular mechanisms of host-pathogen interactions and how these manipulate host immunity. You will become a central part of a team of experienced researchers working both independently and together with a collaborators based at the Universities of Oxford. The project will be centred on a fascinating family of polymorphic cell surface proteins that are expressed by host cells infected with the parasite that causes malaria and how they interact with host immunoregulatory receptors.
Skills, Experience & Qualification needed
You will have:
- A PhD in a biochemistry-related subject or equivalent work experience
- Experience in recombinant protein expression and purification in mammalian cell lines, and ideally experience in cell based human immunological assays
- In depth experience in molecular biology especially site directed mutagenesis
- Expertise in extracellular protein interaction detection (binding assays) and quantitative (surface plasmon resonance)
- Experience in handling human blood cells
- Highly organised and fastidious personality
- Collaborative attitude to support the progress of a wider team
Interview date: to be confirmed
For informal enquiries: please contact Gavin Wright (gavin.wright@york.ac.uk)
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We particularly encourage applications from people who identify as Black, Asian or from a Minority Ethnic background, who are underrepresented at the University.
We offer family friendly, flexible working arrangements, with forums and inclusive facilities to support our staff.
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