We are looking for a talented and motivated research associate to join the group of Dr William Grey based in the York Biomedical Institute, Department of Biology at the University of York. The Grey lab focuses on the proteome and the roles of protein homeostasis in healthy haematopoiesis and acute myeloid leukaemia (AML), with a particular interest in using primary patient material and translating fundamental biological findings to therapeutic targeting. The post is full time, on a fixed term basis for an initial 3 years with 2 years extension available, funded by the Medical Research Council (MRC).
We study the leukaemic stem cell (LSC) compartment of AML using both inducible mouse models (Cancer Cell 2016) and primary patient samples (Sci. Transl. Med. 2022), with a particular focus on the functional state of the proteome (Blood 2020). In this new project, funded by the MRC, we will study how the proteome evolves from healthy haematopoietic stem cell to malignant leukaemic stem cell in vivo.
The successful candidate will benefit from a highly collaborative programme in the U.K. and Europe including; Prof. David Kent (York, U.K., HSC biology), Dr. Anjum Kahn (Leeds, U.K., Consultant haematologist), Prof. Cristina Lo Celso (London, U.K., in vivo imaging), Dr. Andrew Wood (Edinburgh, U.K., degron tagging), Prof. Jurg Schwaller (Basel, Switzerland, inducible mouse models) and Dr. Marieke Essers (Heidleburg, Germany, HSC stress integration). The post holder will also benefit from a multidisciplinary environment locally in Biology (Kent, Hitchcock, Bridge) and colleagues in Chemistry (Fascione, Spicer). The post holder will be expected to balance driving their independent research project alongside managing mouse models and xenograft cohorts for a longitudinal project with a long-term view to research. They will also work closely with other lab members and researchers across the institute and take an active role in proposing PhD projects, supervising students and developing potential new areas of research in the lab.
The successful candidate will have at least an undergraduate degree, a PhD in a biomedical sciences discipline (preferred, not essential), or equivalent experience in haematology, immunology or cancer cell biology. Experience in cell culture and molecular biology techniques (e.g. PCR, qPCR, western blotting and flow cytometry) are desirable. Candidates with experience in using in vivo mouse models, primary stem cell cultures, primary human material and proteomics are particularly encouraged to apply. The successful candidate must have experience of carrying out both independent and collaborative research, writing up research work for publication and a willingness to contribute to the process of securing future research funding.
The post is full time on a fixed term basis of 36 months with a further 24 months extension available and funded by the Medical Research Council. Salary is dependent on experience and qualification of the successful candidate.
Based at: University of York campus (with some remote working options available)
Closing date: 27 January 2023.
Interview date: To be confirmed
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